For an appointment with this fertility specialist, please find a location at UNC School of Medicine or call:

1-919-275-3018

Education & Postgraduate Training

Residency

Yale University School of Medicine

Fellowship

University of North Carolina, Chapel Hill

Board Certification

• American Board of Obstetricians and Gynecologists (ABOG), 1998
• Certification in Reproductive Endocrinology and Infertility, 2000

Professional Societies and Memberships

• Member, The Endocrine Society
• Fellow, American Society for Reproductive Medicine
• Member, Society for Reproductive Endocrinology & Infertility
• Fellow, American College of Obstetrics and Gynecology
• Member, American Association for the Advancement of Science
• Associate Member, Society for Gynecologic Investigation
• Member, American Society for Reproductive Immunology

Clinical Interests

• Ovarian physiology
• Ovulation induction
• IVF (invitro fertilization)
• Recurrent pregnancy loss
• Tubal microsurgery
• Menopause and hormone replacement

Current Publications

• Lesmeister MJ, Jorgenson RL, Young SL, Misfeldt ML . 17ý-Estradiol Suppresses TLR3-Induced Cytokine and Chemokine Production in Endometrial Epithelial Cells. Reproductive Biology and Endocrinology 2005, 3:74
• Jorgenson RL, Young SL, Lesmeister MJ, Lyddon TD, Misfeldt ML. Human Endometrial Epithelial Cells Cyclically Express TLR3 and Exhibit TLR3-Dependent Responses to dsRNA. Human Immunology 2005; 66: 469-82.
• Radhakrishnan Y, Hamil KG, Yenugu S, Young SL, French FS, Hall SH. Identification, characterization, and evolution of a primate b-defensin gene cluster. Genes and Immunity:

Books & Chapters

• Young SL and Loy T. Normal Cycling Endometrium: Molecular, Cellular, and Histologic Perspectives. In: Endometriosis in Clinical Practice. David Olive (ed.) 2004. In Press - 22 page manuscript.
• Young SL, Al-Hendy A and Copland JA. Potential Non-Hormonal Therapeutics for Medical Treatment of Leiomyomas. Seminars in Reproductive Medicine. 2004; 22:121-30.
• Young SL and Lessey BA. Integrins in Endometrium and Endometriosis. In: Endometrium and Endometriosis. Michael Diamond and Kevin Osteen (eds.), Blackwell Science, 1997: 121-130.
• Lessey BA and Young SL. Integrins and Other Cell Adhesion Molecules in Endometrium and Endometriosis. Seminars in Reproductive Endocrinology. 1997; 15: 291-299.
• Melner MH, Allen RG, Young SL, Low KG. Expression of high levels of proenkephalin in an isolated glial cell type: Inhibition by ?-interferon. In Neuropeptides and Immunopeptides, NY Academy of Sciences, 1989.

Refereed Papers

• Young SL, Lyddon TD, Jorgenson RL, Misfeldt ML. Expression of Toll-like Receptors in Human Endometrial Epithelial Cells and Cell Lines. American Journal of Reproductive Immunology 2004; 52:67-73.
• Hoffman RW, Gazitt T, Foecking MF, Ortmann RA, Misfeldt ML, Jorgenson RL, Young SL, Greidinger EL. U1-RNA Induces Innate Immune Signaling. Arthritis & Rheumatism 2004; 50:2891-2896.
• Fang L, Nowicki BJ, Urvil P, Yallampalli U, Goluszko P, Nowicki S, Young SL, Yallampalli C. Epithelial Invasion by Escherichia coli Bearing Dr Fimbriae Is Controlled by Nitric Oxide-Regulated Expression of CD55. Infect Immun 2004; 72: 2907-2914.
• Breitkopf DM, Rosen MP, Young SL, and Nagamani, M. Efficacy of second versus third generation oral contraceptives in the treatment of hirsutism. Contraception 2003; 67: 349-353.
• Lessey BA, Gui Y, Apparao KBC, Yuan L, Young SL, Mullholland J. Regulated Expression of Heparin-Binding Epidermal Growth Factor (HB-EGF) in the Human Endometrium: A Potential Paracrine Role during Implantation. Mol Reprod Dev 2002; 62:446-55.
• Daftary GS , Troy PJ , Bagot CN , Young SL, and Taylor HS. Direct regulation of Beta 3 Integrin subunit gene expression by HOXA10 in endometrial cells. Molecular Endocrinology 2002; 16: 571-9.
• Young SL, Lessey BA, Murray MJ, Fritz, MA, Meyer, WR, Speckman, PL and Nowicki BJ. In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay accelerating factor (DAF). J Clin Endocrinol Metab 2002; 87: 1368-75.
• Young SL, Opsahl MS, Fritz MA. Serum concentrations of clomiphene isomers across multiple consecutive clomiphene citrate treatment cycles. Fertil Steril 1999;71:639-44.
• Young SL, Barbera L, Kaynard AH, Haugland RP, Kang HC, Brinkley M, and Melner MH. A non-radioactive assay for transfected chloramphenicol acetyltransferase activity using fluorescent substrates. Analytical Biochemistry 1991;197; 401-407.
• Young SL, Searles RP, Kaynard AH,. Melner MH. Specific inhibition of Protein Kinase A in Granulosa Cells Abolishes Gonadotropin Regulation of the Proopiomelanocortin Promoter. Journal of Biological Chemistry 1991;266:15839-44.
• Melner MH, Young SL. Intracellular mechanisms of gonadotropin-stimulated gene expression in granulosa cells. Steroids 1991;56: 232-6.
• Hruby DE, Brinkley MJ, Kang HC, Young SL, Melner MH. Fluorescent Chloamphenicol Derivative as a Substrate for CAT Assay. Biotechniques 1990;8: 170-1.
• Saneto RP, Low KG, Young SL, Nielsen CP, Melner MH. The Regulation of Proenkephalin Expression in a Distinct Population of Glial Cells. The EMBO Journal 1990;9: 791-6.
• Young SL, Melner MH. Androgens Amplify ?-Adrenergic and FSH Stimulation of Granulosa Cells. Steroids 1989;54:583-91.
• Young SL, Nielsen CP, Lundblad JL, Roberts JR, Melner MH. Gonadotropin Regulation of the Rat Proopiomelanocortin Promoter: Characterization by transfection of Primary Ovarian Granulosa Cells. Molecular Endocrinology 1989;3:15-21.
• Melner MH, Young SL, Czerwiec FS, Lyn D, Puett D, Roberts JL, Koos RD. The Regulation of Granulosa Cell Proopiomelanocortin Messenger Ribonucleic Acid by Androgens and Gonadotropins. Endocrinology 1986;119: 2082-8.
• Young SL, Jackson AE, Puett D, Melner MH. Detection of Chloramphenicol Acetyl Transferase Activity in Transfected Cells: A Rapid and Sensitive HPLC-based method. DNA 1985;6:469-75.
• Jorgenson RL, Young SL, Lesmeister MJ, Lyddon TD, Misfeldt ML. Human Endometrial Epithelial Cells Cyclically Express TLR3 and Exhibit TLR3-Dependent Responses to dsRNA. Manuscript submitted to Human Immunology 2004.
• Radhakrishnan Y, Hamil KG, Yenugu S, Young SL, French FS, Hall SH. Identification, characterization, and evolution of a primate b-defensin gene cluster. Manuscript submitted 2004.