Marc Fritz, M.D.

UNC Fertility

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Dr. Marc Fritz writes THE book about Reproductive Endocrinology and Infertility – literally!  He is co-author of Clinical Gynecologic Endocrinology and Infertility, the most widely read textbook on this field  in the world, now published in four languages. He serves on essentially all of the prominent national committees in the field, and is widely considered one of the leaders in this specialty. Dr. Fritz grew up in Michigan, attended college at the United States Air Force Academy, and received his M.D. from Tulane University in 1977.  He completed a residency in OB/GYN in the Air Force at the Wright-Patterson Air Force Base medical center and received further advanced subspecialty fellowship training in Reproductive Endocrinology and Infertility at the Oregon Health Sciences University.  After completing his training, he returned to the Air Force and served as a member of the faculty at Wright State University and at the Uniformed Services University of the Health Sciences before coming to Carolina in 1993. Dr. Fritz is Professor of Obstetrics and Gynecology and Chief of the Division of Reproductive Endocrinology and Infertility.  He is board certified in both Obstetrics and Gynecology and in Reproductive Endocrinology and Infertility, and directs both the Assisted Reproductive Technologies program and our fellowship training program at UNC.  He has served on the Executive Board of the American College of Obstetrics and Gynecology, and on the Division of Reproductive Endocrinology and Infertility for the American Board of Obstetrics and Gynecology.  He is a past President of the Society for Reproductive Endocrinology and Infertility and is Chair of the Practice Committee for the American Society for Reproductive Medicine.  Dr. Fritz has authored over 70 scientific articles and chapters for numerous medical journals and textbooks and has been named one of “America’s Top Doctors” every year since the list first appeared in 2001. Dr. Fritz has special interest and expertise in: infertility, in vitro fertilization, ovulation induction, recurrent pregnancy loss, hormonal disturbances, endometriosis, uterine fibroids, and hysteroscopy. Professional Organizations

  • American College of Obstetricians and Gynecologists; - Junior Fellow (1978-1985) and Fellow (1985- present)
  • American Fertility Society/American Society for - Reproductive Medicine
  • Central Association of Obstetricians and Gynecologists
  • Durham-Orange County (NC) Medical Society
  • Endocrine Society
  • North Carolina Medical Society
  • North Crolina Obstetrical and Gynecological Society
  • Society for Gynecologic Investigation
  • Society of Reproductive Endocrinology and Infertility
  • Turner's Syndrome Society
Current Publications
  • Lovely LP, Fazleabas AT, Fritz MA, McAdams DG, Lessey BA. Prevention of endometrial apoptosis: Randomized prospective comparison of hCG versus progesterone treatment in the luteal phase. J Clin Endocrinol Metab 2005; 90:2351-2356.
  • Murray MJ, Meyer WR, Zaino RJ, Lessey BA, Novotny DB, Ireland K, Fritz MA. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 2004; 81:1333-43.
  • Murray MJ, Meyer WR, Lessey BA, Oi R, DeWire RE, Fritz MA. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause 2003;10:456-64.
  • Usadi RS, Murray MJ, Bagnell R, Fritz MA, Kowalik AI, Meyer WR, Lessey BA. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril 2003;79:970-4.
  • Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA, Lessey BA. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Molec Hum Reprod 2002;8:871-9.
  • Gregory CW, Wilson EM, Apparao KB, Lininger RA, Meyer WR, Kowalik A, Fritz MA, Lessey BA. Steroid receptor coactivator expression throughout the menstrual cycle in normal and abnormal endometrium. J Clin Endocrinol Metab 2002;87:2960-6.
  • Young SL, Lessey BA, Fritz MA, Meyer WR, Murray MJ, Speckman PL, Nowicki BJ. In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay accelerating factor. J Clin Endocrinol Metab 2002;87:1368-75.
  • Apparao KBC, Murray MJ, Fritz MA, Meyer WR, Chambers AF, Truong PR, Lessey BA. Osteopontin and its receptor avb3 integrin are co-expressed in the human endometrium during the menstrual cycle but regulated differentially. J Clin Endocrinol Metab 2001; 86:4991-5000.
  • Williams CD, Boggess JF, LaMarque LR, Meyer WR, Murray MJ, Fritz MA, Lessey BA. A prospective, randomized study of endometrial telomerase during the menstrual cycle. J Clin Endocrinol Metab 2001;86:3912-7.
  • Lessey BA, Castelbaum AJ, Wolf L, Greene W, Paulson M, Meyer WR, Fritz MA. The use of integrins to date the endometrium. Fertil Steril 2000;73:779-87.
Education Doctor of Medicine: Tulane University Medical School New Orleans, Louisiana, 1973-1977 Internship USAF Medical Center, Wright-Patterson Wright-Patterson Air Force Base, Ohio, 1977-1978 Residency Department of Obstetrics and Gynecology Wright State University School of Medicine USAF Medical Center, Wright-Patterson Dayton, Ohio, 1978-1981 Fellowship Reproductive Endocrinology and Infertility Oregon Health Sciences University and Oregon Regional Primate Research Center, 1981-1983 American Board of Obstetrics and Gynecology: (recertification), 1985 American Board of Obstetrics and Gynecology, 1996 Division of Reproductive Endocrinology (recertification), 1987 Board Certification
  • Examiner, American Board of Obstetrics and Gynecology, - 1994-1998
  • Examiner, American Board of Obstetrics and Gynecology - Division of Reproductive Endocrinology, 1998-2000
Clinical Interests
  • Ovarian physiology
  • Ovulation induction
  • IVF (invitro fertilization)
  • Recurrent pregnancy loss
  • Tubal microsurgery
  • Menopause and hormone replacement


UNC Fertility