Clomid Side Effects

Has your doctor recommended that you take Clomid? Clomid is the most commonly-prescribed fertility drug. Still, as with any medication, Clomid can cause uncomfortable side effects. Here is what you need to know.

How does Clomid work?
Clomid helps women who ovulate irregularly or not at all. Clomid causes the pituitary gland to secrete more FSH, which starts the development of ovarian follicles containing eggs. If Clomid works for you, eggs are released from the ovary and ovulation occurs.

Clomid success rates are high as the drugs helps to induce ovulation in more than 80 percent of patients who take Clomid. Also, about 50 percent of women become pregnant within six cycles of taking Clomid.

What are Clomid side effects?
Some women report severe side effects on Clomid, but many women tolerate Clomid side effects well. Clomid side effects can even be fairly mild and generally disappear once Clomid is stopped.

With higher doses of this fertility drug, Clomid side effects are more pronounced. About 10 percent of women that take Clomid report Clomid side effects such as:

  • Hot flashes
  • Mood swings
  • Depression
  • Breast tenderness
  • Nausea
  • Headaches
  • Visual disturbances

If you experience any of these Clomid side effects, contact your doctor immediately.

More serious Clomid side effects
Some women may develop more serious Clomid side effects, including ovarian cysts and pelvic discomfort resulting from a hyper stimulation of the ovaries. Warning signs of ovarian hyper stimulation (OHSS) include:

  • Abdominal pain and distention
  • Nausea
  • Vomiting
  • Diarrhea
  • Weight gain

A thinning of the endometrium or a changing of the cervical mucus are other possible Clomid side effects. These complications should be taken seriously, as they can have a negative impact on your chances of a successful pregnancy.

Multiple births and Clomid
Another Clomid side effect is an increased chance of becoming pregnant with multiples. In fact, there is a 10 percent chance of having twins when becoming pregnant with Clomid infertility treatment. With Clomid, there is a less than one percent chance of having triplets or higher.

Multiples may be a welcome blessing for many families dealing with infertility. However, before taking Clomid you should discuss the risk of multiples with your doctor. Becoming pregnant with multiples increases your chances of premature labor. Also, premature babies are at a greater risk for health and developmental problems.

Is Clomid right for you?
As you can see, most Clomid side effects are generally minimal, and go away after treatment is stopped. Still, you should weigh the risks versus the benefits before beginning a course of Clomid or any of the other fertility drugs.



  • RESOLVE: Fertility Medications
  • American Pregnancy Association: Infertility Medications
  • American Society for Reproductive Medicine: Medications for Inducing Ovulation: A Guide for Patients